Surfactant-Associated Protein A Provides Critical Immunoprotection in Neonatal Mice
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چکیده
منابع مشابه
Surfactant-associated protein B is critical to survival in nickel-induced injury in mice.
The etiology of acute lung injury is complex and associated with numerous, chemically diverse precipitating factors. During acute lung injury in mice, one key event is epithelial cell injury that leads to reduced surfactant biosynthesis. We have previously reported that transgenic mice that express transforming growth factor alpha (TGFA) in the lung were protected during nickel-induced lung inj...
متن کاملOverexpression of surfactant protein-C mature peptide causes neonatal lethality in transgenic mice.
Surfactant replacement preparations containing either surfactant protein (SP)-B or SP-C significantly improve lung function in surfactant-deficient infants, suggesting that these peptides may be functionally redundant. SP-B is absent and SP-C is greatly diminished in the airspaces of SP-B (-/-) mice, which die of respiratory distress syndrome (RDS) shortly after birth. The goal of this study wa...
متن کاملSurfactant protein D is proatherogenic in mice.
Surfactant protein D (SP-D) is an important innate immune defense molecule that mediates clearance of pathogens and modulates the inflammatory response. Moreover, SP-D is involved in lipid homeostasis, and pulmonary accumulation of phospholipids has previously been observed in SP-D-deficient (Spd-/-) mice. Atherogenesis involves both inflammation and lipid deposition, and we investigated the ro...
متن کاملCorrigendum to “Two Mutations in Surfactant Protein C Gene Associated with Neonatal Respiratory Distress”
[This corrects the article DOI: 10.1155/2015/591783.].
متن کاملTwo Mutations in Surfactant Protein C Gene Associated with Neonatal Respiratory Distress
Multiple mutations of surfactant genes causing surfactant dysfunction have been described. Surfactant protein C (SP-C) deficiency is associated with variable clinical manifestations ranging from neonatal respiratory distress syndrome to lethal lung disease. We present an extremely low birth weight male infant with an unusual course of respiratory distress syndrome associated with two mutations ...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 2008
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.01043-07